In 1993 and 1994, MCA/Universal Home Video released twelve of the thirteen episodes on six VHS tapes and eight on two Laserdisc volumes. These have been the only home video release of the cartoon in the United States. In the United Kingdom, the 13-episode series was released on six video-cassettes in 1995, which enabled the full series to surface on the internet in English a decade or so later. Episodes have been released on DVD in France, Germany, and Italy, as Universal abruptly abandoned further media reissues after the release of the DTV movies since the late 1990s. At the end of each episode, Fievel, who is the national "spokesmouse" for the Reading Is Fundamental Foundation, did a "Reading Buddy" spot to encourage children to read. These PSAs were not preserved on the VHS releases and may be considered lost, only existing through surviving TV recordings.
In Russia, the cartoon, dubbed in Russian but retaining the original English titles and names, was broadcast on First Channel Russian Television (Russian: ОРТ) in summer 1996 with Woody Woodpecker. Repeat airings were broadcast in Spring 2002 and Winter 2005.
Don Bluth, the director of the original American Tail film, had no involvement with the series. Phillip Glasser and Dom DeLuise were the only two actors from the original film to reprise their roles, as Fievel and Tiger respectively. Cathy Cavadini, however, did reprise the role as Tanya, whom she voiced in the second film, taking over the role from Amy Green.
This series has only appeared on VHS in the United States and UK, while there have been DVD releases in France, Germany, and Italy. Since the release of the DTV sequels in the late 1990s, Universal abruptly abandoned this show from further home media reissues until it was recovered by NBCUniversal in 2020 and have it available to stream on Peacock in the future.
Three notable characters are written out from this show:
Wylie Burp was written out due to his voice actor, James Steward, retired from voice acting, five years prior to his death.
Tony Toponi was written out due to his voice actress Pat Musick had some personal issues involving her then-current parenting with her daughter Mae Whitman (who was 3-4 years old at the time), as she rarely did any work during that period, with the exception of doing voices for couple episodes of Batman: The Animated Series.
This is the final An American Tail media Phillip Glasser voiced Fievel Mousekewitz due to the changing of his voice by age, as further production of the franchise was put in hiatus until a half of decade later when Thomas Dekker took over the voice for Fievel.
An American Tail is the only Bluthless franchise to feature Simpsons legend Dan Castellaneta and Powerpuff Girls legend Cathy Cavadini.